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. Author manuscript; available in PMC: 2016 Sep 22.
Published in final edited form as: Oncogene. 2016 Feb 15;35(35):4641–4652. doi: 10.1038/onc.2016.1

Figure 7. PIK3CA, PDK1 and pAKT alterations in human HNSCCs.

Figure 7

(a) qRT-PCR quantitation of PIK3CA mRNA expression in human HNSCCs. Error bars indicate mean±SD. *p<0.05. NN: Normal controls; Adj: adjacent mucosa; Well: well differentiated tumors; Mod: moderately differentiated tumors; Poorly: poorly differentiated tumors; LN mets: Lymph node metastases.

(b) Percentage of human HNSCC cases which exhibited ≥2+ IHC staining of p110α, PDK1, and pAKT. Well: well differentiated tumors; Mod: moderately differentiated tumors; Poorly: poorly differentiated tumors; LN mets: Lymph node metastases. *p<0.05.

(c) IHC staining of serial sections of a poorly differentiated HNSCC. Scale bar: 50 μm.