Table 1.
Incidence of tertiary lymphoid tissue development in human and mouse intestine.
| Condition/model | Location | Lymphoid component(s) | Reference |
|---|---|---|---|
| Human | |||
| Helicobacter Pylori | Stomach | B/T cells, HEV, CXCL13 | (120, 121) |
| Crohn’s disease | Ileum/Colon | B/T cells, lymphoid follicular inflammation | (44–46, 122) |
| Ilectomy (Crohn’s disease) | Terminal ileum | Aphthous ulcers, ulcers >8mm, fibrotic strictures rare | (48) |
| Colorectal carcinoma | Colon | B/T cells, FDC, CXCL13, CCL19, CCL21 | (123, 124) |
| Mice | |||
| Disease model | |||
| Autoimmune gastritis | Stomach | B/T cells, CXCL13, FDC, autoantibodies | (125, 126) |
| Helicobacter Pylori | Stomach | B/T cells, FDC, GC, CXCR5, CXCL13 | (127–129) |
| TNF-transgenic (TNFΔARE) | Ileum | B/T cells, FDC, GC CCL19, CCL21, CXCL13 | (13, 34) |
| Prion disease (LTα−/−/LTβ−/−) | Small intestine | B cells, FDC, CR1/CR2 | (130) |
| DSS-colitis (RORγt−/−) | Colon | B/T cells, Th1, autoantibodies, LTBR-dependent | (49) |
| DSS-colitis (LTα−/−) | Colon | B/T cells, CD8 | (59) |
| Anti-LTβR in utero | Small intestine | B/T cells, GC, IgA, Th17 | (25, 32, 59) |
| Genetic model | |||
| CCR7−/− | Stomach | B/T cells, FDC, CCL21, CXCL13 | (131) |
| AID−/− | Small intestine | B/T cells, FDC, hyper IgM | (132) |
| CnAalpha+/− | Small intestine | B/T cells, CD11b, TFG-β, IFNγ | (133) |
| IL-25−/− | Small intestine | B cells, CD11b, CD11c | (134) |
| CXCL13-transgenic | Ileum | LTi, IL-22, LTα, LTβ, CXCL13 | (65) |