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Effects of high-fat diet and rAAV-Lep pretreatment and high-fat diet on bone marrow adiposity (A), adipocyte density (B), and adipocyte size (C) in distal femur metaphysis in male WT and ob/ob mice, respectively. RCD, regular control diet. HFD, high-fat diet. Data are mean ± SE (n = 3–9/group). aDifferent from RCD within WT, P < 0.05.
