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Receptor binding and functionality profiles of EXT5 and EXT9
| Compound | Ki | IC50 | ||||
|---|---|---|---|---|---|---|
| 5‐HT2A | 5‐HT2B | 5‐HT2C | 5‐HT2A | 5‐HT2B | 5‐HT2C | |
| EXT5 (μmol/L) | 1.01 | 0.045 | 0.31 | 7.54 | 0.082 | 5.11 |
| EXT9 (μmol/L) | 0.46 | 0.026 | 0.11 | 0.84 | 0.029 | 0.65 |
Ki, inhibition constant; IC50, half maximal inhibitory concentration.
