Table 3.

Proteins coimmunopurified with β2*-nAChRs from postmortem human temporal cortex with abundances that correlate significantly with the abundance of the β2 nAChR subunit

Accession	Description	Correlation (r)	p Value	n
ACHB2_HUMAN	Neuronal acetylcholine receptor subunit β2	1	0	18
ACHA4_HUMAN	Neuronal acetylcholine receptor subunit α4	0.972	<0.0009	18
AT1B1_HUMAN	Sodium/potassium-transporting ATPase subunit β1	0.889	<0.0009	18
AT1A3_HUMAN	Sodium/potassium-transporting ATPase subunit α3	0.888	<0.0009	18
SNP25_HUMAN	Synaptosomal-associated protein 25	0.88	<0.0009	18
STX1B_HUMAN	Syntaxin-1B	0.874	<0.0009	18
AT1A1_HUMAN	Sodium/potassium-transporting ATPase subunit α1	0.871	<0.0009	18
ANK2_HUMAN	Ankyrin-2	0.856	<0.0009	18
STX1A_HUMAN	Syntaxin-1A	0.844	<0.0009	18
GPM6A_HUMAN	Neuronal membrane glycoprotein M6-a	0.823	<0.0009	18
AT2B2_HUMAN	Plasma membrane calcium-transporting ATPase 2	0.781	<0.0009	18
GNAO_HUMAN	Guanine nucleotide-binding protein G(o) subunit α	0.781	<0.0009	18
VPP1_HUMAN	V-type proton ATPase 116 kDa subunit a isoform 1	0.777	<0.0009	18
MYPR_HUMAN	Myelin proteolipid protein	0.762	<0.0009	18
GBB1_HUMAN	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit β1	0.702	0.001	18
EAA2_HUMAN	Excitatory amino acid transporter 2	0.701	0.001	18
VA0D1_HUMAN	V-type proton ATPase subunit d 1	0.644	0.004	18
MYH9_HUMAN	Myosin-9	0.631	0.005	18
AT1A2_HUMAN	Sodium/potassium-transporting ATPase subunit α2	0.609	0.007	18
TBB5_HUMAN	Tubulin β chain	0.576	0.012	18
TBA1A_HUMAN	Tubulin α1A chain	0.56	0.016	18
1433Z_HUMAN	14-3-3 protein zeta/delta	0.548	0.019	18
STXB1_HUMAN	Syntaxin-binding protein 1	0.526	0.025	18
SYT1_HUMAN	Synaptotagmin-1	0.523	0.026	18
CLH1_HUMAN	Clathrin heavy chain 1	0.515	0.041	18
TBA4A_HUMAN	Tubulin α4A chain	0.514	0.029	18
S10A7_HUMAN	Protein S100-A7	0.511	0.03	18
TBA1B_HUMAN	Tubulin α1B chain	0.506	0.032	18
RO52_HUMAN	E3 ubiquitin-protein ligase TRIM21	0.492	0.038	18
ODO2_HUMAN	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex	0.483	0.042	18
TBB4A_HUMAN	Tubulin β4A chain	0.476	0.046	18
MYO5A_HUMAN	Unconventional myosin-Va	0.475	0.046	18
TPM4_HUMAN	Tropomyosin α4 chain	0.473	0.047	18

High correlation indicates the identified protein is either specifically interacting with the receptor at the time of tissue lysis or is part of a complex that stays intact following extraction in Triton X-100. The cluster of proteins with correlation coefficients <0.7 is evidence of significant enrichment of presynaptic components critical for neurotransmitter release and neuronal excitability.