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. 2016 Aug 16;6:31437. doi: 10.1038/srep31437

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Copyright © 2016, The Author(s)

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(a) H2ACtT regulates the open and closed conformations of linker DNA by binding to different locations. The linker DNA is freely fluctuating when H2ACtT binds to the entry/exit region of DNA; whereas it is tightly constrained close to nucleosome core when H2ACtT binds to the distal end of linker DNA, resulting in the closed conformation of nucleosome. (b) H3NtT binds to the linker DNA in different patterns and regulates exposure of DNA at entry/exit region. H3NtTs without helix or compact coil conformations do not influence DNA conformation visibly. H3NtTs with helix or compact coil conformations tend to change the local curvature of DNA. The curvature changes potentially lead to exposure of the DNA at the entry/exit region to the solvent.