Figure 2. Dose-dependent cell viability (MTT assay) of human corneal endothelial cells (CECs) treated with ribonuclease (RNase) 5.

Relative CEC viability compared to controls over 48 hours according to the concentration of RNase 5. The number of viable CECs was significantly elevated compared to control by RNase 5, and the lowest concentration of RNase 5 showing maximal CEC viability was 5 μg/mL at all three timepoints (12-, 24- and 48-hour treatments). **p < 0.01, vs. control; ^##p < 0.01 and ^#p < 0.05, vs. 5 μg/mL of RNase 5 (ANOVA followed by Bonferroni’s post-hoc analysis). n = 4 independent experiments at all three timepoints. Values represent the mean ± s.e.m.