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. 2016 Aug 16;6:31664. doi: 10.1038/srep31664

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) NCI/ADR-RES cells were incubated with various concentrations of MPT0G066 (0.1–3 μM) or paclitaxel (1–30 μM) for 48 h. Cell viability was analyzed by MTT assay. (B) NCI/ADR-RES cells were treated with various concentrations of MPT0G066 (0.1–1 μM) or paclitaxel (1 μM) for 48 h. The whole cell lysates were subject to western blot analysis with caspase-3, PARP and actin. (C) NCI/ADR-RES cells were treated with or without indicated agent and co-treated with 1 μM rhodamine 123 (RHO). After 1 h incubation at 37 °C, cells were collected and analyzed by flow cytometry. BLK, blank; VPL, verapamil (50 μM); Paclitaxel (30 μM); G066, MPT0G066 (1, 3, 10 μM).