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. 2016 Aug 16;6:31664. doi: 10.1038/srep31664

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Copyright © 2016, The Author(s)

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(A) SKOV3 and (B) A2780 cells were incubated with MPT0G066 (0.01–0.3 μM) and cisplatin alone or increasing concentration (1.25–20 μM) for 48 h. Left panel: cell viability was determined by MTT assay. Right panel: CI values for combination of MPT0G066 and cisplatin. The resulting combination index (CI) theorem of Chou-Talalay offers quantitative definition for additive effect (CI = 1), synergetic effect (CT > 1), and antagonism effect (CI < 1) in drug combinations. Fa represented fraction of cells affected.