Table 5a. Distribution of the proportion of patients with pigment epithelial detachment on optical coherence tomography examination at baseline and 12-month follow-up.

	Baseline	12 Months	P-value
All patients (presence/72)	46% (33/72)	40% (29/72)	0.40
PRN regimen	36% (13/36)	28% (10/36)	0.46
Fixed regimen group (loading phase+2q8)	56% (20/36)	53% (19/36)	0.99
PRN group vs fixed regimen group	(p: 0.15)	(p: 0.05)

Abbreviations: fixed regimen, loading phase+bimonthly injections; PED, pigment epithelial detachment; PRN, pro re nata strategy.

No remarkable reduction in the presence of PED was recorded in both groups during the period study.