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. 2016 Apr 25;47(3):195–204. doi: 10.1093/labmed/lmw017

Figure 1.

Figure 1

The GSTM1 gene is situated at chromosome 1 (1p13.3), composed of 8 exons, spanning a region of 21,244 bases. GSTM1 null allele arose from a recombination event resulting in deletion of a 20-kb segment. This deletion produces a novel 7.4-kb HindIII fragment with the loss of 10.3- and 11.4-kb HindIII fragments, hence homozygotes for GSTM1 null allele produce no GSTM1 protein. The end points of the polymorphic GSTM1 deletion are: the left repeated region 5 kb downstream from the 3’-end of the GSTM2 gene and 5 kb upstream from the beginning of the GSTM1 gene; the right repeated region 5 kb downstream from the 3’-end of the GSTM1 and 10 kb upstream from the 5’-end of the GSTM5 gene.