. 2016 Apr 25;47(3):195–204. doi: 10.1093/labmed/lmw017

Table 3.

Individual and Combined GSTM1 and GSTT1 Genotypes as Risk Factors for EOS, EOBP, and EOFEP

	Disorder Type
GST Genotype	EOS	EOBP	EOFEP
GSTM1 active ^a
Ca/Co	22/141	5/141	13/141
OR (95% CI)	1.00 [reference]	1.00 [reference]	1.00 [reference]
P value
GSTM1 null^b
Ca/Co	28/137	7/137	18/137
OR (95% CI)	1.86 (.74-4.66)	2.33 (.58-9.37)	2.24 (.72-6.95)
P value	.18	.23	.16
GSTT1 null^b
Ca/Co	9/65	4/65	9/65
OR (95% CI)	1.00 [reference]	1.00 [reference]	1.00 [reference]
P value
GSTT1 active^a
Ca/Co	41/213	8/213	22/213
OR (95% CI)	1.65 (.53-5.09)	.42 (.90-2.05)	1.00 (.27-3.69)
P value	.38	.28	.99
GSTM1 active/GSTT1 null
Ca/Co	4/42	2/42	2/42
OR (95% CI)	1.00 [reference]	1.00 [reference]	1.00 [reference]
P value
GSTM1 active/GSTT1 active
Ca/Co	18/99	3/99	11/99
OR (95% CI)	1.43 (.32-6.43)	.75 (.08-6.08)	2.10 (.33-13.34)
P value	.63	.80	.42
GSTM1 null/GSTT1 null
Ca/Co	5/23	2/23	7/23
OR (95% CI)	2.52 (.29-22.17)	2.36 (.24-24.32)	5.16 (.51-51.53)
P value	.39	.47	.16
GSTM1 null/GSTT1 active
Ca/Co	23/114	5/114	11/114
OR (95% CI)	2.9 (.65-12.90)	.67 (.11-4.05)	4.16 (.60-28.68)
P value	.160	.67	.14

GST, glutathione S-transferase; EOS, early-onset schizophrenia spectrum disorder; EOBD, early-onset bipolar disorder; EOFEP, early-onset first-episode psychosis; Ca/Co, no. of case vs control individuals; OR, odds ratio, adjusted for age and sex; CI, confidence interval

^aActive (present) if at least one active allele is present.

^bInactive (null) if no active alleles present.