Table 2. Area Under the ROC curves for advanced (stage 2 or 3) AKI, or Composite Outcome.
| T3 | T6 | T9 | T12 | T24 | |
|---|---|---|---|---|---|
| Advanced AKI | |||||
| α-GST | 0.477 (0.267–0.686) | 0.489 (0.301–0.678) | 0.508 (0.349–0.668) | 0.395 (0.205–0.584) | 0.604 (0.416–0.791) |
| adjusted α-GST$ | 0.395 (0.215–0.575) | 0.435 (0.271–0.599) | 0.448 (0.297–0.599) | 0.366 (0.204–0.529) | 0.515 (0.359–0.671) |
| π-GST | 0.784 (0.673–0.895)# | 0.649 (0.456–0.843) | 0.767 (0.610–0.924)# | 0.552 (0.360–0.743) | 0.597 (0.414–0.780) |
| adjusted π-GST$ | 0.675 (0.546–0.804)* | 0.529 (0.369–0.688) | 0.587 (0.426–0.749) | 0.384 (0.221–0.547) | 0.413 (0.273–0.554) |
| Composite outcome | |||||
| α-GST | 0.553 (0.366–0.739) | 0.533 (0.372–0.693) | 0.537 (0.398–0.676) | 0.451 (0.286–0.616) | 0.619 (0.462–0.775) |
| adjusted α-GST$ | 0.455 (0.291–0.620) | 0.448 (0.298–0.597) | 0.454 (0.314–0.593) | 0.397 (0.251–0.543) | 0.513 (0.379–0.647) |
| π-GST | 0.783 (0.682–0.884)# | 0.675 (0.512–0.837)* | 0.763 (0.626–0.900)# | 0.603 (0.432–0.774) | 0.619 (0.461–0.777) |
| adjusted π-GST$ | 0.670 (0.549–0.792)* | 0.521 (0.375–0.667) | 0.565 (0.415–0.714) | 0.407 (0.255–0.558) | 0.413 (0.280–0.545) |
Expressed as AUC (95% confidence interval); *p < 0.05, #p < 0.005 against AUC = 0.5 by C statistics.
$concentration divided by urine creatinine level.
GST, glutathione S-transferase.
**labeled as 3 hours [T3], 6 hours [T6], 9 hours [T9], 12 hours later [T12], and 24 hours post-surgery [T24].