Figure 8. The acute oral toxicity of by241 on mice and antitumor efficacy in MGC-803 bearing nude model.

(A) Body weight of mice in 15 days after oral treatment with by241 (250, 500 or 1000 mg/kg). MGC-803 cells were transplanted subcutaneously to the BALB-C nude mice and subjected to by241 (40, 80 and 120 mg/kg), 5-FU (15 mg/kg) and saline were used as the negative control for 21 days. (B) Tumor size and (C) body weight measurements every 2 days from MGC-803 mice after by241 administration. (D) Photographs of mice in saline group, 5-FU group and by241 (120 mg/kg) group and (E) Photographs of tumors in each group. (F) Comparison of the final tumor weight in each group after 21-day treatment. Data are presented as means ± SD. **P < 0.01 was considered statistically significant compared with the negative control.