Table 1. In vitro cytotoxicity of by241 against several human cancer cell lines and two human normal cell lines.
| IC50 (μM)a | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| EC109 | EC9706 | KYSE450 | MGC-803 | BGC-803 | SMMC-7721 | ZIP77 | MCF-7 | PC-3 | Het-1A | L-02 | |
| by241 | 5.62 ± 0.75 | 4.68 ± 0.67 | 8.73 ± 0.94 | 2.77 ± 0.44 | 1.18 ± 0.71 | 4.83 ± 0.68 | 2.71 ± 0.43 | 6.25 ± 0.80 | 6.36 ± 0.80 | 20.15 ± 1.50 | 21.80 ± 1.34 |
| 5-FU | 9.31 ± 0.12 | 8.96 ± 0.33 | nd | 4.02 ± 0.27 | 2.23 ± 0.04 | 2.14 ± 0.25 | 3.32 ± 0.04 | 6.93 ± 0.03 | 15.03 ± 0.96 | nd | 4.37 ± 0.23 |
aInhibitory activity was assayed by exposure for 72 h to substances and IC50 is the concentration of by241 required to inhibit the cell growth by 50% compared to an untreated control. Data are presented as the means ± SDs of three independent experiments; nd means not determined.