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Arginines in the Lsm4 RGG domain are required for PB accumulation. (A) Indirect IF assays for Dcp1a (red) in HEK 293 T-REx cells treated with an siRNA against Lsm4 and induced to express the AGG and KGG mutant Lsm4 proteins. DAPI staining is shown in blue to mark nuclei. (B to D) Quantification of PBs by the PB markers indicated in three independent experiments. Error bars represent standard deviations. **, P < 0.01; *, P < 0.05 (Student's paired two-tailed t test).
