FIG 2.

Gata3^g/g mice exhibit renal deformity. (A) Gata3^g/g neonate (P0) mouse shows atrophic kidney in comparison with wild-type control. Note that Gata3^g/g mouse shows no urinary collection in bladder (asterisk). (B, C) Gata3^g/g mouse shows significant thinning of renal cortex and robust renal fibrosis in the medullary region (asterisks in panel C), while the wild-type kidney shows a normal histological appearance. Scale bar, 0.5 mm. (D) Gata3^g/g neonate shows robust increase of mRNA expression of renal injury markers, Kim1 and Ngal (WT, n = 5; g/g, n = 6; statistical significance of differences is indicated: **, P < 0.05 by Student's unpaired t test). (E, F) Gata3^g/g kidney shows a reduced number of glomeruli in comparison with the wild-type control (circles). Remaining glomeruli in Gata3^g/g kidney show diminished cellularity and often associate with enlarged glomerular capillary. Bar, 50 μm.