FIG 7.
Expression of glomerulus and tubule-related genes in the young G3YR mice. Glomerular (A) and tubular (B) fractions of kidney from wild-type and G3YR (Gata3g/g::TgB125-G3) mice are separately subjected to RT-qPCR analysis. (C) Gene expression signature in the glomerular cells. Expression of Pdgfra and Pdgfrb, a mesangial-cell-specific marker, is significantly decreased in the G3YR mice. Podocin and Nephrin, two representative podocyte markers, are relatively maintained. Megsin, a serine protease inhibitor, is highly induced in the G3YR mice. Statistical significances in differences are indicated (WT, n = 7; G3YR, n = 7; *, P < 0.05; Student's unpaired t test). (D) Gene expression signature in tubular cells. Ae1 and Aqp2, two target genes of the GATA factor, are comparably expressed in the G3YR and wild-type mice.