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Mesangionephritis in the G3YR mice. Gata3 is expressed in both tubular cells and glomerular mesangial cells (GMC). The 625-kb Gata3 YAC directs Gata3 expression in tubular cells but not mesangial cells. G3YR (Gata3g/g::TgB125-G3) mice show mesangionephritis because the B125 Gata3 YAC fails to complement GATA3 in mesangial cells.
