Table 3.
Comparison of clinical variables of SNPs in rs2282440-SDC3
| Gene (SNP) |
SDC3 (rs2282440) |
p Value | |||
|---|---|---|---|---|---|
| Genotype | C/C and C/T (N=444) |
T/T (N=143) |
|||
| Dependent variable | Mean | SE | Mean | SE | |
| BMI (kg/m2) | 26.39 | 0.24 | 27.65 | 0.42 | 0.010 |
| Waist circumference (cm) | 83.46 | 0.68 | 87.05 | 1.21 | 0.010 |
| Hip circumference (cm) | 99.24 | 0.51 | 101.90 | 0.90 | 0.009 |
| Waist-to-hip ratio | 0.84 | 0.00 | 0.85 | 0.01 | NS |
| Body fat (%) | 32.19 | 0.38 | 34.04 | 0.68 | 0.018 |
| SBP (mm Hg) | 123.70 | 0.77 | 125.90 | 1.35 | NS |
| DBP (mm Hg) | 77.59 | 0.55 | 78.67 | 0.98 | NS |
| Heart rate (bpm) | 76.28 | 0.62 | 76.82 | 1.09 | NS |
| Cholesterol (mg/dL) | 196.50 | 1.74 | 196.30 | 3.07 | NS |
| Triglyceride (mg/dL) | 110.00 | 4.03 | 125.40 | 7.10 | 0.059 |
| LDL-C (mg/dL) | 118.50 | 1.57 | 118.60 | 2.78 | NS |
| HDL-C (mg/dL) | 56.17 | 0.66 | 53.41 | 1.17 | 0.040 |
| Glucose (mg/dL) | 94.64 | 1.12 | 97.20 | 1.97 | NS |
| Insulin (µU/mL) | 11.09 | 0.61 | 12.52 | 1.07 | NS |
| HOMA-IR | 2.83 | 0.21 | 3.24 | 0.37 | NS |
| hs-CRP (mg/dL) | 0.21 | 0.02 | 0.22 | 0.03 | NS |
BMI, body mass index; DBP, diastolic blood pressure; HDL-C, high-density lipoprotein cholesterol; HOMA-IR, homeostatic model assessment-insulin resistance; hs-CRP, high-sensitive C reactive protein; LDL-C, low-density lipoprotein cholesterol; NS, not significant;
SBP, systolic blood pressure.
Analysis of covariance (ANCOVA): covariates are age and gender.