Table 2.

In-vitro cytotoxicity of quinolines (9a-9e).

Compound	R 1	R 2	IC 50 (µM)	Survival a (%) (10µM )		IC 50 (µM)	Survival b (%) (25µM)
			MCF-7	48h 72h		T47D	48h 72h
9d	cyclohexyl		<5	4	0.7	25	49.1	26.1
9a	Ph	H	<10	38.3	26.7	<25	33.8	25.4
9c	Phenyl		10	48.4	41.3	50	75.8	68.9
9b	Me	Me	25	61	47.2	50	66.2	69.5
9e	H	H	>25	67.2	58.2	25	47.4	47.5
Doxorubicin	-	-	0.25	50.2	31.7	0.1	53.2	27.1

^a Percent survival of MCF-7 cells following exposure to 10 µM concentration of compounds was determined after 48 h and 72 h exposure using MTT assay.

^b Percent survival of T47D cells following exposure to 25 µM concentration of compounds was determined after 48 h and 72h exposure using MTT assay.