Table 7.
Anti-inflammatory effects of drug loaded and placebo nanoemulsion gel in carrageenan-induced rat paw edema
| Group | Formulation | N | Mean weight ±SD (g) | Time (h) | % Mean Edema ± SD | % Inhibition |
|---|---|---|---|---|---|---|
| I | Control | 6 | 180.0±12.3 | 1 | 29.2±2.3 | |
| (carrageenan only) | 2 | 43.01±4.2 | ||||
| 3 | 76.25±3.3 | |||||
| 6 | 59.11±3.7 | |||||
| 12 | 39.3±3.01 | |||||
| II | Drug loaded | 6 | 190±10.01 | 1 | 25.5±2.4 | 12.67 |
| nanoemulsion hydrogel | 2 | 33.15±2.8 | 22.92 | |||
| 3 | 46.20±4.1 | 39.40 | ||||
| 6 | 14.10±1.8 | 76.16 | ||||
| 12 | 6.09 ±1.2 | 84.55 | ||||
| III | Placebo | 6 | 195.0±12.3 | 1 | 27.3 ±3.1 | 6.50 |
| nanoemulsion hydrogel | 2 | 36.6 ±3.7 | 14.90 | |||
| 3 | 53.19 ±3.4 | 30.37 | ||||
| 6 | 36.12 ±3.1 | 38.89 | ||||
| 12 | 23.17±2.5 | 41.04 |
N = Number of rats in each group; SD = Standard deviation