Table 5.

Tabulated statistical evaluation of the responses and validation of experimental design

A. Summary of each factor effect on responses Y 1 , Y 2 and Y3
FACTOR	Y 1				Y 2				Y 3
	Factor effect		P value		Factor effect		P value		Factor effect			P value
X1	-0.020		0.0133		2.21		0.0013		0.13		0.0508
X2	-38.3		0.9756		1.68		0.0016		0.23		0.0128
X1X2	1.56		0.0034		-0.29		0.0036		-0.15		0.0673
X12	-.358		0.1064		-6.56		0.3303		0.20		0.0716
X22	-1.06		0.0281		-0.69		0.0003		0.21		0.7957
B. Model summary statistics for quadratic response surface model
RESPONSE FACTOR		F-value		P>F		R 2		Adequate precision		C.V
Y1		13.65		0.0133		0.9317		11.406		1.66
Y2		110.56		0.0013		0.9946		30.934		0.69
Y3		10.80		0.0391		0.9474		8.786		1.92
C. Validation of experimental design by evaluation of extra design check point formulation N10
Evaluation parameters		Predicted value		Actual value		% Error		Evaluation parameters		Predicted value
Particle size (nm)		167.03		164.6		1.823		Particle size (nm)		167.03
% Entrapment efficiency		74.38		72.65		2.381		% Entrapment efficiency		74.38
% CDR after 12 hrs		91.39		91.23		0.175		% CDR after 12 hrs		91.39