Fig. 1.

Comparison of wet cell weight (a) and cell dry weight (b) at 10,000 and 10 L scale. The green and orange lines represent the temporal biomass accumulation profiles at 10 and 10,000 L, respectively. In b the specific growth rates are from the best linear fit of the semi-LN plot of CDW versus elapsed fermentation time (EFT) in hours (hr). Plotted CDW, WCW values are average of 9 and 7 batches at 10 and 10,000 L scale, respectively. In both panels the two parallel-dashed lines delimitate the transition time between fast- and slow-growing cells during fed-batch. Error bars represented one standard deviation