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N-glycosylation linkages are derived from N-acetyl-glucosamine (GlcNAc), mannose (Man) and glucose (Glu). These sugars are added consecutively onto dolichol, a poly isoprenoid lipid carrier embedded in the endoplasmic reticulum (ER) membrane. 3 UDP Glu and 4 GDP Man from the cytoplasm were bound to dolichol first via a pyrophosphate linkage (–PP–). After the Man5GlcNAc2-PP-dolichol intermediate is completed, the entire complex is flipped into the lumen of the ER
