Table 2.
Comparative analysis of multivariable models (ridge) for prognostication of OS and PFS
| OS | PFS | |||||
|---|---|---|---|---|---|---|
| PEV % | c-index | P | PEV % | c-index | P | |
| Clinics | 8.77 | 0.69 | <0.001 | 17.0 | 0.68 | <0.001 |
| AID/APOBEC | 2.53 | 0.59 | 0.025 | n.a. | n.a. | n.a. |
| Combined | 11.13 | 0.70 | <0.001; 0.021* | 13.6 | 0.65 | <0.001; 0.320* |
Cross-validated performance assessment of Cox regression models (ridge) by proportion of explained variation (PEV), concordance index (c-index) and p-value. Models were developed using (i) clinicopathological variables designated as Clinics; (ii) AID/APOBEC multigene-based variables designated as AID/APOBEC; (iii) their combination designated as Combined
* p-value for added value of AID/APOBEC on top of Clinics in bivariable models with cross-validated predictors