Figure 5.

Specific reduction in synaptic protein levels upon MeCP2 depletion at an advanced adult stage. Quantitative western blot analysis showing significant reduction in the levels of selective synaptic proteins in the whole brains of 15 W-Tam-injected Mecp2^loxJ/CreER male mice when compared with the brains of the 15 W-Veh-injected Mecp2^loxJ/CreER littermate control male mice. The Mann–Whitney U-test was used to compare within Veh- and Tam-injected groups. Error bars are mean ± SEM. *P < 0.05, **P < 0.01. n = 3 mice per group.