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mRNA changes in three genes on ubiquitin proteolysis pathway. Semi-quantitative RT-PCR demonstrates the mRNA levels of BRCA1 (A), TSPYL5 (B) and PEX10 (C) in five CON18W and five T2118W cases, with significant down-regulation in TSPYL5. The quantification is shown below (***P ≤ 0.001).
