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. 2016 Feb 16;25(9):1739–1753. doi: 10.1093/hmg/ddw045

Figure 1.

Figure 1.

Immunoblotting analysis of proteins in mutant Htt neurons treated with MitoQ and SS31 and in untreated mutant Htt neurons. (A) Representative immunoblotting analysis of mutant Htt neurons treated with MitoQ and SS31 and untreated Htt neurons. (B) Quantitative densitometry analysis of mitochondrial dynamics and the matrix proteins Drp1, Fis1, Mfn1, Mfn2, Opa1 and CypD in the mutant Htt neurons treated with MitoQ and SS31 and in the untreated Htt neurons. The fission proteins Drp1 and Fis1 were significantly decreased; and the fusion proteins Mfn1, Mfn2, and Opa1, and the synaptic, synaptophysin, PSD95, and DARPP32 proteins were significantly increased in the MitoQ- and SS31-treated Htt neurons, indicating that MitoQ and SS31 reduce fission activity and enhance fusion and synaptic activity.