Table 1.

mRNA fold changes of mitochondrial dynamics, mitochondrial biogenesis, electron transport chain, and synaptic genes in mutant Htt neurons (HDhQ111/Q111) treated with MitoQ and SS31

Genes	MitoQ	SS31
	Fold changes	Fold changes
Mitochondrial dynamics genes
DRP1	−1.5*	−2.1*
FIS1	−1.4*	−1.9*
Mfn1	1.8*	1.2
Mfn2	1.7*	1.4*
Cyclophilin D	−1.2	−2.0*
OPA1	1.2	1.4*
VDAC1	−1.4*	−1.1
Mitochondrial biogenesis genes
PGC1α	1.9**	1.3*
PGC3β	1.5*	2.0**
Nrf1	1.5*	1.1
Nrf2	1.4*	1.2
TFAM	1.4*	1.3*
Mitochondrial-encoded electron transport chain genes
ND1 - Complex I	1.3*	1.4*
ND3 - Complex I	1.2	1.1
ND6 - Complex I	1.1	1.1
Cyt B - Complex III	1.3*	1.2
COX1 - Complex IV	1.3*	1.4*
COX2 - Complex IV	1.5*	1.6*
COX3 - Complex IV	1.6*	1.5*
ATP6 - Complex V	1.2	1.4*
Synaptic genes
Synaptophysin	1.1	1.4*
PSD-95	1.9*	1.8*
Synapsin 1	1.5*	1.6*
Synapsin 2	1.3*	1.1
Synaptobrevin 1	1.5*	1.7*
Synaptobrevin 2	1.2	1.1
Neurogranin	1.5*	1.2
GAP43	1.7**	1.4*
Synaptopodin	1.2	1.2