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. 2016 Feb 21;25(9):1792–1802. doi: 10.1093/hmg/ddw051

Figure 2.

Figure 2.

XJB-5-131 treatment prevents weight reduction and decreases hair loss and graying phenotypes in HdhQ(150/150) and controls with age. (A) A representative example of the hair loss on the forehead and dorsal side (A, Panel 3) that developed in a HdhQ(150/150)-vh (HD-vh) mouse at 120 weeks of age. (B) A representative example of ‘salt and pepper’ coats developed in HD-vh animals at 120 weeks, particularly around the temples, muzzle and underside at old ages (in this case 120 weeks of age). The coat appearance of HD-tr (60 + 60weeks treatment) animals was indistinguishable from that of age-matched WT-vh or WT-tr animals of 120 weeks (A, Panels 1, 2 and 4). (C) Quantification of the hair loss and graying phenotypes (in A and B) among mice at 120 weeks, expressed as a percentage of all animals in their treatment group, WT-vh (n = 37), HD-vh (n = 46), HD-tr (n = 34). (D) The weight of male HD-vh mice with age relative to control littermates. XLB-5-131 promotes weight gain at 40 weeks of treatment (P < 0.05, Student's t-test, one-tailed homoscedastic). WT-vh (n = 7), HD-vh (n = 12), HD-tr (n = 9).