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. 2016 Feb 13;25(9):1814–1823. doi: 10.1093/hmg/ddw053

Figure 2.

Figure 2.

Slc52a3 KO mouse is embryonic lethal. (A and B) Day 9.5 embryos resulting from heterozygous mutant mice crossing. (A) Genotyping PCR results. (B) Recovered embryos of each genotype. Bar; 300 μm. (C and D) Day 10.5 embryos resulting from heterozygous mutant mouse crossing. (C) Genotyping PCR results. (D) Recovered embryos of each genotype. Homozygous KO embryos have severe developmental abnormality. Bar; 1 mm. (E) TUNEL assay in E10.5 embryos of each genotype. Bars: 100 μm. (F) Ratio of TUNEL positive cells to DAPI positive cells. **P < 0.01.