Table 2.
Univariate analysis of different prognostic factors for survival in 335 patients with sHCC (Cox proportional hazards regression)
| Variable | Overall survival | Recurrence-free survival | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Gender (male vs. female) | 0.825 (0.374–1.816) | 0.825 | 0.663 (0.366–1.202) | 0.176 |
| Age (>48 vs. ≤48 years) | 1.014 (0.615–1.672) | 0.331 | 1.171 (0.829–1.654) | 0.371 |
| ALT (≤40 vs. >40 U/L) | 1.337 (0.812–2.201) | 0.949 | 1.272 (0.902–1.795) | 0.170 |
| AFP (≤20 vs. >20 ng/mL) | 1.230 (0.734–2.059) | 0.130 | 0.912 (0.644–1.289) | 0.601 |
| Tumor size (≤2.5 vs. > 2.5 cm) | 2.431 (1.443–4.093) | 0.014 | 1.710 (1.211–2.415) | 0.002 |
| Tumor differentiation (well-moderate vs. poor-undifferentiated) | 1.215 (0.679–2.175) | 0.172 | 1.774 (1.221–2.578) | 0.003 |
| Vascular invasion (absent vs. present) | 3.033 (1.827–5.035) | 0.001 | 1.790 (1.236–2.594) | 0.002 |
| Envelope (absent vs. present) | 0.920 (0.544–1.559) | 0. 110 | 0.958 (0.668–1.375) | 0. 816 |
| Liver cirrhosis (absent vs. present) | 1.516 (0.921–2.495) | 0.496 | 1.329 (0.939–1.881) | 0.108 |
AFP alpha-fetoprotein, ALT alanine aminotranferease, HR hazards ratio, CI confidence interval