Table 6.
Molecular findings
| Bunker [39] | Kilian et al. [33] | Lho et al. [19] | Uhthoff and Boileau [41] | Xu et al. [37] | ||
|---|---|---|---|---|---|---|
| Techniques used | IHC | X | X | X | X | |
| ICC | X | |||||
| RTPCR | X | X | ||||
| ELISA | X | |||||
| Matrix components | Fibroblasts | ↑ | ↓ | ↑ | ||
| Myofibroblasts | ↑ | ↓ | ||||
| Cytokines | IL- 1α | ↑ | ||||
| IL-1β | ↑ | |||||
| IL-6 | ↑ | |||||
| TNF-α | ↑ | |||||
| Immune factors | Leukocytes | ↓ | ||||
| Macrophages | ↓ | |||||
| Neuronal factors | PGP9.5 | ↑ | ||||
| GAP43 | ↑ | |||||
| P75 | ↑ | |||||
| Vascular factors | CD34 | ↑ | ||||
| Enzymes | COX1 | ↑ | ||||
| COX2 | ↑ |
↑ (increased), ↓ (decreased), IHC (immunohistochemistry analysis), ICC (immunocytochemical examination), RTPCR (real time reverse transcription-polymerase chain reaction), ELISA (enzyme-linked immunosorbent assay), IL-1α (interleukin 1 alpha), IL-1β (interleukin 1 beta), IL-6 (interleukin 6), TNF-α (tumour necrosis factor alpha), PGP9.5 (polyclonal rabbit antiprotein gene product 9.5), GAP43 (monoclonal mouse antigrowth-associated protein 43), P75 (nerve growth factor receptor p75), CD34 (monoclonal mouse antihuman CD34), COX1 (cyclooxygenase 1), COX 2 (cyclooxygenase 2)