Table 2.
Promising Thelohanellus kitauei-Specific Drug Targets (23) Relating to Nutrient Process
| Gene ID | Predicted Protein | Function Category | Previous Indications As Drug Target |
|---|---|---|---|
| evm.model.scaffold04826.5 | Peptidyl-prolylcis-trans isomerase FKBP4 | Transport | Antiparasitic targets (Ibrahim and Nishikawa 2012) |
| evm.model.scaffold05481.72 | Vesicular glutamate transporter 3 | ||
| evm.model.scaffold02466.3 | |||
| evm.model.scaffold00373.8 | Integrin beta 2 | Endocytosis | Antiinflammatory target (de Gaetano et al. 2013) |
| evm.model.scaffold04701.1 | Heterogeneous nuclear ribonucleoprotein K | Anticancer target (Benelli et al. 2009) | |
| evm.model.scaffold01071.3 | Sortilin | Target for Alzheimer's disease (Caglayan et al. 2014) | |
| evm.model.scaffold01071.5 | |||
| evm.model.scaffold05633.24 | Low-density lipoprotein-related protein 2 | Target for Alzheimer's disease (Martiskainen et al. 2013) | |
| evm.model.scaffold04423.69 | |||
| evm.model.scaffold01248.6 | Arachidonate 5-lipoxygenase | Lipid metabolism | Anticancer target (Chen et al. 2009) |
| evm.model.scaffold04176.12 | 17 beta-estradiol 17-dehydrogenase | Anticancer target (Szajnik et al. 2012) | |
| evm.model.scaffold00813.1 | Diacylglycerol kinase (ATP dependent) | Targets for cancer (Dominguez et al. 2013) | |
| evm.model.scaffold04610.1 | Phospholipase D3 | Target in disease settings (Huang and Frohman 2007) | |
| evm.model.scaffold05340.25 | Oligosaccharyltransferase complex subunit beta | Glycan biosynthesis | Target for Aspergillus fumigatus (Li et al. 2011) |
| evm.model.scaffold00661.36 | 2,3-bisphosphoglycerate-independent phosphoglyceratemutase | Carbohydrate metabolism | Anticancer (Ren et al. 2010)/antifilarial (Singh et al. 2013) target |
| evm.model.scaffold03068.51 | Inositol-tetrakisphosphate 1-kinase | Antimalarial target (Stritzke et al. 2012) | |
| evm.model.scaffold01538.6 | Inositol-1,4,5-trisphosphate 5-phosphatase | Antimalarial target (Stritzke et al. 2012) | |
| evm.model.scaffold01687.1 | Ribokinase | Antibacterial target (Desroy et al. 2009) | |
| evm.model.scaffold04623.113 | Pyrazinamidase/nicotinamidase PNCA | Cofactor metabolism | Target for Leishmania (Gazanion et al. 2011) |
| evm.model.scaffold02481.37 | |||
| evm.model.scaffold03983.31 | Thiamine pyrophosphokinase | Antimalarial target (Chan et al. 2013) | |
| evm.model.scaffold04174.4 | Ectonucleoside triphosphate diphosphohydrolase 4 | Nucleotide metabolism | Anticancer target (Tada et al. 2011) |
| evm.model.scaffold02448.28 | Glutathione S-transferase | Other amino acid metabolism | Antimesothelioma (De Luca et al. 2013) /antimalarial (Harwaldt et al. 2002) target |