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Independent clade 5 PaLoc acquisitions are supported by the crosspopulation phylogeny of tcdB functional domains. Phylogenies constructed from the four domains of tcdB: (A) The glucosyltransferase domain, (B) the cysteine protease domain, (C) the translocation domain, and (D) the receptor-binding domain. Colored labels indicate clade (see Key). Strain labels are shown in supplementary figure S1, Supplementary Material online.
