Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jul 25;213(8):1513–1535. doi: 10.1084/jem.20151775

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 Quek et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 8. — Complex clonal hierarchies in samples where NPM1 mutation is acquired first also have expanded LSC-containing CD34⁻CD117⁺ populations. (A and B) NPM1-mutated clones underwent clonal selection and evolution in xenotransplanted mice. Data from two patients and the number of single cells analyzed per population. (A) Patient #875: CD34⁺, n = 35; CD34⁻CD117⁺, n = 35. (B) Patient #449: CD34⁺, n = 26; CD34⁻CD117⁺, n = 47. Panels i–iv are as in Fig. 7. Ery-pre, erythroid precursor; loh, loss of heterozygosity.