Table 1:
Basic demographic and clinical characteristics of patients stratified according to the presence of anti-AT1R antibodies before Heart Mate II implantation and throughout the support
| AT1R-positive before HMII implantation (n = 8) | AT1R-positive during HMII support (n = 44) | AT1R-negative (n = 17) | P-value | |
|---|---|---|---|---|
| Age (years) | 49 (41, 58) | 51 (39, 59) | 48 (41, 58) | 0.875* |
| BSA (m2) | 1.81 (1.66, 2.03) | 1.97 (1.81, 2.10) | 2.01 (1.91, 2.13) | 0.118* |
| BMI | 21 (20, 25) | 25 (23, 27) | 27 (24, 29) | 0.054* |
| Female gender (%) | 1 (12.5) | 7 (15.9) | 1 (5.9) | 0.580† |
| Diabetes (%) | 1 (12.5) | 8 (18.2) | 3 (17.6) | 0.926† |
| COPD (%) | 1 (12.5) | 7 (15.9) | 2 (11.8) | 0.905† |
| Previous stroke (%) | 2 (25) | 10 (22.7) | 2 (11.8) | 0.596† |
| INTERMACS I,II (%) | 2 (25) | 27 (61.4) | 10 (58.9) | 0.158† |
| Ischaemic aetiology of HF (%) | 2 (25) | 16 (36.4) | 5 (29.4) | 0.902† |
| HLA sensitized (%) | 0 | 3 (8.6) | 0 | 0.354† |
| Previous sternotomy (%) | 1 (12.5) | 8 (18.2) | 4 (23.5) | 0.792† |
| Previous VA ECMO | 0 | 4 (9.1) | 0 | 0.299† |
| After HMII implantation | ||||
| Concomitant procedure (%) | 14 (31.8) | 2 (11.8) | 0.110† | |
| PRBC (units) | 10 (7, 14) | 9 (7, 17) | 0.863** | |
| Platelets (units) | 4 (3, 6) | 3 (2, 5) | 0.159** | |
| FFP (units) | 24 (18, 35) | 26 (16, 31) | 0.700** | |
| Major bleeding (%) | 6 (13.6) | 0 | 0.173† | |
| Major infection (%) | 11 (25) | 5 (29.4) | 0.725† | |
| Neurological dysfunction (%) | 1 (2.3) | 0 | 0.531† | |
| Device malfunction (%) | 1 (2.3) | 1 (5.9) | 0.478† | |
| ARBs during support (%) | 8 (18.2) | 1 (5.9) | 0.206† | |
| HLA sensitized during support (%) | 13 (30.2) | 7 (41.2) | 0.418† | |
| Mean BP on support (mmHg) | 85 (80, 90) | 90 (81, 99) | 0.048** | |
| Duration of support (months) | 9 (5, 16) | 11 (5, 16) | 0.705** | |
BSA: body surface area; BMI: body mass index; COPD: chronic obstructive pulmonary disease; INTERMACS: Interagency Registry for Mechanically Assisted Circulatory Support; HF: heart failure; HLA: human leucocyte antigen; HMII: Heart Mate II; VA ECMO: veno-arterial extracorporeal membrane oxygenation; PRBC: pure red blood cell; FFP: fresh frozen plasma; ARB: angiotensinogen receptor blocker; BP: blood pressure.
*Kruskal–Wallis test.
**Mann–Whitney U-test.
†Fisher's exact test.