Table 1.

Number of patients with fungal keratitis due to Acanthamoeba, bacteria, and fungal causes at Aravind Eye Hospital, August 2006–July 2009. The total count of unique individuals is shown by study year. The total number of cases for which cultures were performed is labeled “Number of cultures, all”. The three right columns report, respectively, the result of a test for overall temporal trend, the Edwards test for a 12-month (annual) cycle, and the Edwards test for a 6-month (biannual) cycle (see text for details).

Culture				Number of patients			Overall Trend (P-value)	Annual Cycle	Biannual Cycle
				8/06 to 7/07	8/07 to 7/08	8/08 to 7/09
Number of cultures, all				1620	1814	1787	0.17	0.17	< 0.001
	Number of negative cultures			653	808	732	-	-	-
	Number of positive cultures	All organisms		967	1006	1055	0.38	0.002	< 0.001
		Fungi	Total fungal positive	572	644	692	0.15	0.007	< 0.001
			Fusarium	262	253	292	0.34	0.83	< 0.001
			Other	310	391	400	-	-	-
		Bacteria	Total bacterial positive	378	348	355	0.47	0.30	0.31
			Streptococcus pneumoniae	140	113	126	0.60	0.58	0.04
			Nocardia	29	30	29	0.89	0.12	0.92
			Pseudomonas	82	94	87	0.89	< 0.001	0.26
			Mycobacteria	0	5	3	0.18	0.04	0.49
			Other	127	106	110	-	-	-
		Acanthamoeba		17	14	8	0.56	< 0.001	0.014