Skip to main content
. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Trends Endocrinol Metab. 2016 Apr 21;27(6):404–414. doi: 10.1016/j.tem.2016.03.018

Figure 3. Region-specific roles for LXR signaling in development and homeostasis.

Figure 3

Global roles of LXRs in the brain include regulation of cholesterol homeostasis and inflammation. LXRs have also been implicated in myelination, especially in the corpus callosum and cerebellum, and are important regulators of CSF production in the ventricles and water transport at the BBB. LXRs also have important roles in neuronal function, and have been observed to regulate neurogenesis of red nucleus neurons and dopaminergic neurons in the midbrain as well as neuron migration in the cortex and cerebellum.