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. Author manuscript; available in PMC: 2017 Feb 4.
Published in final edited form as: N Engl J Med. 2016 Jul 6;375(5):443–453. doi: 10.1056/NEJMoa1603144

Figure 1. Presumed Pathogenic Germline Mutations.

Figure 1

Locations of mutations and domains in proteins encoded by 16 predisposition genes are shown by lollipop structures, with the mutation type indicated by color. Protein domains are also distinguished by color. On the graph of each gene, the x axis reflects the number of amino acid residues, and the y axis represents the total number of mutations identified. Of the 20 genes analyzed, 4 (BAP1, BARD1, MLH1, and XRCC2) had no presumed pathogenic germline mutations.