Figure 1.

c-Jun expression is induced in HBV⁺ mice. (a) Hepatic c-Jun mRNA expression at the indicated time points was determined by qPCR and normalized to the expression in HBV^- livers (n≥4 per genotype and time point, significance was tested by Mann–Whitney test). (b) Hepatic expression of AP-1 family members in mice with the indicated genotypes at 6 months of age was analyzed by RNase protection assay. Gapdh expression was used as loading control. (c) c-Jun expression in livers of 6-month-old mice with the indicated genotypes as determined by immunohistochemistry. Note the expression in hepatocytes (black arrows) and inflammatory cells (red arrows)