Figure 2.

Liver tumorigenesis is strongly reduced in 12-month-old HBV⁺ mice lacking c-Jun. (a) Macroscopical images of representative livers of mice with the indicated genotypes. Black bar=1 cm. (b) Liver weight was determined as liver/body weight ratio, (n=4–21 per genotype, significance was tested by Mann–Whitney test (MWT)). (c) Liver tumorigenesis was quantified histologically and is given as tumor numbers per cm² liver tissue. Tumor load was determined as a ratio of tumorous tissue and non-tumorous tissue and is given in (%). Significance was tested by MWT