Table 1. Effects of FOXO3 with and without EtOH on pro- and anti-apoptotic gene mRNA expression.
Target gene | FOXO3 | FOXO3/EtOH | |
---|---|---|---|
Anti-apoptotic | BCL2 | 30.7 | 1.1 |
BIRC2 | 2.3 | 0.6 | |
BIRC3 | 9.5 | 3.4 | |
BNIP3L | 4.0 | 1.3 | |
TNFRSF1B | 23.1 | 4.0 | |
Pro-apoptotic | TNF | 11.6 | 14.0 |
TNFRSF9 | 12.2 | 20.3 | |
TNFRSF8 | 3.9 | 18.7 | |
IL10 | 3.4 | 6.3 |
Data are expressed as mRNA fold elevation compared with Huh7.5 cells that were not transfected with FOXO3 or treated with EtOH