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. Author manuscript; available in PMC: 2016 Aug 16.
Published in final edited form as: J Mol Med (Berl). 2012 Jan 7;90(6):707–718. doi: 10.1007/s00109-011-0851-2

Figure 6. Diagram of a proposed novel EGR1/AE2/P16/P-ERK signal pathway in colon cancer cells.

Figure 6

EGR1 transcriptionally upregulates AE2 expression. AE2 polypeptide interacts with and sequesters P16 in the cancer cell cytoplasm. Cytoplasmic P16 promotes phosphorylation of ERK, which can translocate into the nucleus, and activate cyclin D1 to promote cell proliferation. Gastrin acts through CCKBR at the plasma membrane to decrease EGR1 expression. Blockade of the EGR1/AE2/P16/P-ERK signaling pathway inhibits growth of colon cancer cells.