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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Curr Opin Hematol. 2016 May;23(3):253–259. doi: 10.1097/MOH.0000000000000239

Figure 2.

Figure 2

Adhesive molecules of the endothelial cell-cell junction. The vascular permeability barrier is maintained by tight junctions comprised of claudins, occludins, and JAMs, followed by adherens junctions comprised primarily of vascular endothelial cadherin (VE-cadherin) associated with the actin cytoskeleton via members of the catenin family. Underneath these specialized compartments lies the most abundant endothelial cell surface receptor, PECAM-1, which is expressed at 1–2 x 106 molecules per cell. Figure adapted from E. Dejana, Nature Reviews Molecular Biology 5:261, 2004 (69).