Table 1.

Effect of Diabetes and Glycemic Control on Change in Body Weight, Blood Glucose and Serum Triglycerides, Free Fatty Acids, Cholesterol and Nitrotyrosine and Dorsal Root Ganglion Nitrotyrosine and 4-Hydroxynonenal (4-HNE)

Determination	Control	Diabetic	Diabetic Poor Glycemic Control	Diabetic Good Glycemic Control	Diabetic Poor Switched to Good Glycemic Control
	(11)	(10)	(11)	(11)	(12)
Start weight (g)	23.7 ± 0.6	24.5 ± 0.4	23.5 ± 0.5	23.3 ± 0.5	23.7 ± 0.5
End weight (g)	31.9 ± 0.9	27.3 ± 0.8a	27.1 ± 0.6a	28.1 ± 0.8a	27.8 ± 0.6a
Blood glucose (mg/dl)	131 ± 3	589 ± 2a	363 ± 9a,b	251 ± 9a,b,c	304 ± 9a,b,c,d
Serum Triglycerides (mg/dl)	41.3 ± 7.1	76.3 ± 6.8a	53.1 ± 6.4	46.7 ± 4.6b	47.8 ± 6.2b
Serum Free fatty acids (mmol/l)	0.26 ± 0.03	0.68 ± 0.09a	0.43 ± 0.05b	0.36 ± 0.06b	0.37 ± 0.05b
Serum Cholesterol (mg/ml)	0.29 ± 0.03	0.58 ± 0.04a	0.41± 0.03b	0.39 ± 0.03b	0.40 ± 0.03b
Serum Nitrotyrosine (pmol/mg protein)	3.8 ± 0.4	5.7 ± 0.8	5.1 ± 0.7	4.3 ± 0.5	4.9 ± 0.7
DRG Nitrotyrosine (RFU/cell area (mm2))	291 ± 13	383± 32a	311 ± 14	261 ± 18b	300 ± 17
DRG 4-HNE (RFU/cell area (mm2))	264 ± 22	363 ± 21a	346 ± 22a	324 ± 16	336 ± 22

Total duration of diabetes was 20 weeks. Data are presented as the mean ± S.E.M.

^ap < 0.05 compared to control;

^bp < 0.05 compared to untreated diabetic;

^cp < 0.05 compared to diabetic poor glycemic control;

^dp < 0.05 compared to diabetic good glycemic control.

Parentheses indicate the number of experimental animals.