Figure 4.
Light microscopy of a SCLC CTC tumorosphere. Adherent SCLC CTCs in tissue culture eventually start to form 3-dimensional structures under regular tissue culture conditions (A: BHGc10, left side of culture; magnification 100fold) which later grow into large tumorospheres (B: BHGc7, diameter of tumorosphere 560 µm; magnification 40fold). A large and irregular agglomeration of NCI-H526 cells in suspension is shown for comparison (C: magnification 40fold).