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. 2016 Aug 8;57(10):4084–4099. doi: 10.1167/iovs.16-19949

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(A) Immunostaining of frozen lens section from 6-week-old Tmod1^+/+ mice for ezrin (green) and F-actin (red). Ezrin is present along the membranes of lens fiber cells and enriched at the vertices of cortical fibers and along the short sides of mature fiber cells. (B) Immunostaining of frozen lens section from 6-week-old Tmod1^+/+ mice for fimbrin (green) and F-actin (red). Fimbrin is present in epithelial and fiber cells. In fiber cells, fimbrin is distributed along the membrane in differentiating and mature fiber cells. (C, D) Immunostaining of single mature fiber cells (2D, single optical plane) from 6-week-old Tmod1^+/+ and Tmod1^−/− lenses for fimbrin (green), F-actin (red), and ezrin (blue). As expected, ezrin colocalizes with F-actin along the cell membrane and in interdigitations of Tmod1^+/+ and Tmod1^−/− fibers. Interestingly, fimbrin is enriched in puncta near the base of small interlocking protrusions in Tmod1^+/+ and Tmod1^−/− fibers (arrows in [C, D]). Enlargements show ezrin enrichment (arrowheads in [D]) at the base of small protrusions. Scale bars: 20 μm (A, B); 4 μm (C); 2 μm (D).