Table 2:

Five-year survival rates according to clinicopathological features

Characteristic	No. of patients	5-year overall survival after the second pulmonary resection (%)	Univariate analysis
			P-value†	HR	CI
Overall	33	55
Age (years)
≤65	16	72
>65	17	46	0.108	1.931	0.629–5.933
Gender
Women	14	53
Men	19	66	0.831	0.738	0.248–2.203
Smoking habits
Non-smoker	13	61
Current or former smoker	10	50	0.806	1.226	0.342–4.388
Unknown	10
CEA
Within normal range	16	90
Elevated	16	47	0.002*	3.749	1.031–13.632
Unknown	1
Primary site
Colon	12	44
Rectum	21	79	0.221	0.544	0.181–1.632
Prior resection of liver metastasis
Yes	23	76
No	10	39	0.128	2.261	0.748–6.832
Dukes' stage
A-B	6	72
C-D	18	58	0.298	2.293	0.366–23.376
Unknown	9
Histological differentiation
Well differentiated	8	82
Moderately/poorly differentiated	19	56	0.183	2.764	0.550–13.878
Unknown	6
Number of pulmonary metastases
≤2	22	53
>2	11	59	0.298	0.556	0.121–2.552
Maximum tumour size (cm)
≤1	17	58
>1	16	52	0.531	1.19	0.376–3.772
Interval between the primary resection and the second pulmonary resection (months)
≤36	15	47
>36	18	59	0.478	0.606	0.201–1.825
Interval between the first pulmonary resection and the second pulmonary resection (months)
≤12	18	49
>12	15	60	0.554	0.706	0.236–2.114

CEA: preoperative serum carcinoembryonic antigen levels, normal upper limit at 5 ng/ml; HR: hazard ratio for death; CI: confidence interval.

^†Log-rank test.

^*Significance.